GOR V server for protein secondary structure prediction
نویسندگان
چکیده
SUMMARY We have created the GOR V web server for protein secondary structure prediction. The GOR V algorithm combines information theory, Bayesian statistics and evolutionary information. In its fifth version, the GOR method reached (with the full jack-knife procedure) an accuracy of prediction Q3 of 73.5%. Although GOR V has been among the most successful methods, its online unavailability has been a deterrent to its popularity. Here, we remedy this situation by creating the GOR V server.
منابع مشابه
Consensus Data Mining (CDM) Protein Secondary Structure Prediction Server: Combining GOR V and Fragment Database Mining (FDM)
One of the challenges in protein secondary structure prediction is to overcome the cross-validated 80% prediction accuracy barrier. Here, we propose a novel approach to surpass this barrier. Instead of using a single algorithm that relies on a limited data set for training, we combine two complementary methods having different strengths: Fragment Database Mining (FDM) and GOR V. FDM harnesses t...
متن کاملCombining the GOR V algorithm with evolutionary information for protein secondary structure prediction from amino acid sequence.
We have modified and improved the GOR algorithm for the protein secondary structure prediction by using the evolutionary information provided by multiple sequence alignments, adding triplet statistics, and optimizing various parameters. We have expanded the database used to include the 513 non-redundant domains collected recently by Cuff and Barton (Proteins 1999;34:508-519; Proteins 2000;40:50...
متن کاملProtein structure prediction and conformational transitions
There is a critical need for protein structure and function prediction. Accurate protein secondary structure prediction is essential for many bioinformatics applications, including protein tertiary structure prediction. We developed an algorithm (Fragment Data Mining, FDM) for protein secondary structure prediction using fragments of known structures obtained by multiple sequence alignment (MSA...
متن کاملCombining Artificial Neural Networks and GOR-V Information Theory to Predict Protein Secondary Structure from Amino Acid Sequences
Protein secondary structure prediction is a fundamental step in determining the 3D structure of a protein. In this paper, a new method for predicting protein secondary structure from amino acid sequences has been proposed and implemented. Cuff and Barton 513 protein data set is used in training and testing the prediction methods under the same hardware, platforms, and environments. The newly de...
متن کاملA Consensus Data Mining secondary structure prediction by combining GOR V and Fragment Database Mining.
The major aim of tertiary structure prediction is to obtain protein models with the highest possible accuracy. Fold recognition, homology modeling, and de novo prediction methods typically use predicted secondary structures as input, and all of these methods may significantly benefit from more accurate secondary structure predictions. Although there are many different secondary structure predic...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Bioinformatics
دوره 21 11 شماره
صفحات -
تاریخ انتشار 2005